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Product Information: Defluoro Dolutegravir

Chemical Structure of Defluoro Dolutegravir

Defluoro Dolutegravir

Cat. No. HXT-74004
CAS. No. 1863916-88-4
Category Impurities
Stock Status Instock
Molecular Formula C20H20FN3O5
Molecular Weight 401.39 mol/g
Synonyms (4R,12aS)-N-(4-Fluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
Application Defluoro Dolutegravir is an impurity of Dolutegravir, a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

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Reference: Information on this page is gathered from several sources including: PubChem

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