Product Information: 10-Deacetylbaccatin III
10-Deacetylbaccatin III
| Cat. No. | HXO-31076 |
|---|---|
| CAS. No. | 32981-86-5 |
| Category | Impurities |
| Stock Status | Instock |
| Molecular Formula | C29H36O10 |
| Molecular Weight | 544.59 mol/g |
| Synonyms | Docetaxel Impurity E |
| Application | "Impurity in commerial preparation of Baccatin.;Impurity in commercial preparations of Baccatin. Cabazitaxel intermediate. 10-Deacetylbaccatin III is an inhibitor of microtubule assembly (IC50s = 23 and 0.9 ?M for porcine brain and Physaram microtubules, respectively) found in T. baccata extracts.1 It is a precursor in the semisynthetic synthesis of paclitaxel (Item No. 10461) and other semisynthetic toxoids.2 10-Deacetylbaccatin III also selectively inhibits growth of L. donovani intracellular amastigotes within J774 murine macrophages (IC50 = 70 nM), while having no effect on macrophage morphology.3" |
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